About: Tyrosine Kinase Inhibitor

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Attributes	Values
rdf:type	Class
rdfs:label	Tyrosine Kinase Inhibitor
rdfs:subClassOf	Protein Kinase Inhibitor
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Tyrosine Kinase Inhibitor
UMLS_CUI	C1268567
ALT_DEFINITION	A drug that interferes with cell communication and growth and may prevent tumor growth. Some tyrosine kinase inhibitors are used to treat cancer.NCI-GLOSS
Legacy_Concept_Name	Tyrosine_Kinase_Inhibitor
CHEBI_ID	CHEBI:38637
FULL_SYN	Protein Tyrosine Kinase InhibitorsSYNCI TK InhibitorsSYNCI tyrosine kinase inhibitorPTNCI-GLOSSCDR0000044833 PTK InhibitorsSYNCI Tyrosine Kinase InhibitorPTNCI
DEFINITION	Any substance that inhibits tyrosine kinase, an enzyme involved in the transduction and processing of many extracellular and intracellular signals including cell proliferation. Inhibition of tyrosine kinase may result in inhibition of cell growth and cell proliferation.NCI
code	C1967
is rdf:first of	nodeID://b737435 nodeID://b737436 nodeID://b737437 nodeID://b737438
is rdfs:subClassOf of	Src/Abl Kinase Inhibitor AZD0424 pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493 pan FGFR Inhibitor ARQ 087 Volitinib Spleen Tyrosine Kinase Inhibitor GS-9973 Lavendustin A Lavendustin C Lavendustin B Tyrosine Kinase Inhibitor SU5402 SU4984 Lestaurtinib Tandutinib Neratinib Pazopanib Hydrochloride SU014813 SUNITINIB Receptor Tyrosine Kinase Inhibitor R1530 Linifanib MET Tyrosine Kinase Inhibitor BMS-777607 Crizotinib MET Tyrosine Kinase Inhibitor SGX523 Src Kinase Inhibitor KX2-391 Multitargeted Tyrosine Kinase Inhibitor JNJ-26483327 Multitargeted Tyrosine Kinase Inhibitor MGCD265 c-Met Inhibitor JNJ-38877605 Ponatinib Hydrochloride MET Tyrosine Kinase Inhibitor PF-04217903 Pacritinib VEGFR/PDGFR Tyrosine Kinase Inhibitor TAK-593 Masitinib Mesylate Masitinib Foretinib Telatinib Toceranib Toceranib Phosphate c-Met Inhibitor AMG 208 Rebastinib Tosylate Tivozanib Picropodophyllin Telatinib Mesylate VEGFR Inhibitor KRN951 JAK2 Inhibitor TG101348 Multitargeted Tyrosine Kinase Inhibitor PLX3397 Momelotinib MET Tyrosine Kinase Inhibitor EMD 1214063 Multikinase Inhibitor 4SC-203 c-Met Inhibitor INCB028060 JAK2 Inhibitor XL019 c-Met Inhibitor MK2461 MET Tyrosine Kinase Inhibitor EMD 1204831 VEGF Inhibitor PTC299 JAK2 Inhibitor AZD1480 WEE1 Inhibitor MK-1775 VEGFR Tyrosine Kinase Inhibitor c-Met Inhibitor AMG 337 JAK2 Inhibitor BMS-911543 VEGFR/FGFR Dual Kinase Inhibitor E-3810 c-Met Inhibitor LY2801653 MEK Inhibitor GDC-0623 TOFACITINIB Tofacitinib Citrate VEGFR/PDGFR Dual Kinase Inhibitor X-82 cFMS Tyrosine Kinase Inhibitor ARRY-382 MET Tyrosine Kinase Inhibitor SAR125844 VEGFR2 Tyrosine Kinase Inhibitor PF-00337210 JAK2/Src Inhibitor NS-018 FMS Inhibitor JNJ-40346527 FLT3/KIT Kinase Inhibitor AKN-028 Hypoxia-activated Prodrug PR610 ALK Inhibitor CH5424802 EGFR Inhibitor HM61713 ALK Inhibitor X-396 Butein Fruquintinib BTK Inhibitor ONO-4059 IGF-1R Inhibitor PL225B EGFR Inhibitor ABT-414 ALK Inhibitor RO5424802 Daidzein Genistein

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