About: VEGFR2 Tyrosine Kinase Inhibitor PF-00337210     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • VEGFR2 Tyrosine Kinase Inhibitor PF-00337210
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • VEGFR2 Tyrosine Kinase Inhibitor PF-00337210
NCI_META_CUI
  • CL430557
PDQ_Open_Trial_Search_ID
  • 709389
PDQ_Closed_Trial_Search_ID
  • 709389
FULL_SYN
  • VEGFR2 Tyrosine Kinase Inhibitor PF-00337210PTNCI
  • PF-00337210CNNCI
DEFINITION
  • An orally available ATP-competitive inhibitor of the vascular endothelial growth factor receptor type 2 (VEGFR2), with potential anti-angiogenesis and antineoplastic activities. Upon administration, the VEGFR2 tyrosine kinase inhibitor PF-00337210 selectively binds to VEGFR2 and prevents its phosphorylation which may result in an inhibition of migration, proliferation and survival of endothelial cells, microvessel formation, the inhibition of tumor cell proliferation, and may eventually cause tumor cell death. VEGFR2, a receptor tyrosine kinase, is frequently overexpressed by a variety of tumor types.NCI
code
  • C97950
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