About: c-Met Inhibitor MK2461     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • c-Met Inhibitor MK2461
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • c-Met Inhibitor MK2461
NCI_META_CUI
  • CL376145
PDQ_Open_Trial_Search_ID
  • 560555
PDQ_Closed_Trial_Search_ID
  • 560555
FULL_SYN
  • MK2461CNNCI
  • c-Met Inhibitor MK2461PTNCI
DEFINITION
  • A selective small-molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. c-Met inhibitor MK2461 preferentially inhibits activated c-Met in an ATP-competitive manner, thereby inhibiting its tyrosine kinase activity, which may inhibit c-Met signaling and result in cell growth inhibition in tumors that overexpress c-Met. c-Met, encoding the hepatocyte growth factor receptor (HGFR) tyrosine kinase, plays an important role in tumor cell proliferation and has been shown to be overexpressed or mutated in a variety of cancers.NCI
code
  • C90591
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