About: Spleen Tyrosine Kinase Inhibitor GS-9973     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Spleen Tyrosine Kinase Inhibitor GS-9973
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Spleen Tyrosine Kinase Inhibitor GS-9973
PDQ_Open_Trial_Search_ID
  • 746910
PDQ_Closed_Trial_Search_ID
  • 746910
FULL_SYN
  • GS-9973CNNCI
  • Spleen Tyrosine Kinase Inhibitor GS-9973PTNCI
  • SYK Inhibitor GS-9973SYNCI
DEFINITION
  • An orally available inhibitor of spleen tyrosine kinase (Syk), with potential antineoplastic activity. Upon oral administration of spleen tyrosine kinase inhibitor GS-9973, this agent may inhibit the activity of Syk, which inhibits B-cell receptor (BCR) signaling and leads to an inhibition of tumor cell activation, migration, adhesion and proliferation. Syk, a non-receptor cytoplasmic, BCR-associated tyrosine kinase, is expressed in hematopoietic tissues and is often overexpressed in hematopoeitic malignancies.NCI
code
  • C105402
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