About: MET Tyrosine Kinase Inhibitor SGX523     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MET Tyrosine Kinase Inhibitor SGX523
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MET Tyrosine Kinase Inhibitor SGX523
UMLS_CUI
  • C2346913
PDQ_Open_Trial_Search_ID
  • 588972
PDQ_Closed_Trial_Search_ID
  • 588972
Legacy_Concept_Name
  • MET_Tyrosine_Kinase_Inhibitor_SGX523
FULL_SYN
  • MET Tyrosine Kinase Inhibitor SGX523PTNCI
  • SGX523CNNCI
DEFINITION
  • An orally bioavailable small molecule, c-Met inhibitor with potential antineoplastic activity. MET receptor tyrosine kinase inhibitor SGX523 specifically binds to c-Met protein, or hepatocyte growth factor receptor (HGFR), preventing binding of hepatocyte growth factor (HGF) and disrupting the MET signaling pathway; this agent may induce cell death in tumor cells expressing c-Met. c-Met, a receptor tyrosine kinase overexpressed or mutated in many tumor cell types, plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and in tumor angiogenesis.NCI
code
  • C74062
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