About: Multitargeted Tyrosine Kinase Inhibitor PLX3397     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multitargeted Tyrosine Kinase Inhibitor PLX3397
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Multitargeted Tyrosine Kinase Inhibitor PLX3397
NCI_META_CUI
  • CL413557
PDQ_Open_Trial_Search_ID
  • 659167
PDQ_Closed_Trial_Search_ID
  • 659167
FULL_SYN
  • Multitargeted Tyrosine Kinase Inhibitor PLX3397PTNCI
  • PLX3397CNNCI
DEFINITION
  • A capsule formulation containing a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor PLX3397 binds to and inhibits phosphorylation of stem cell factor receptor (KIT), colony-stimulating factor-1 receptor (CSF1R) and FMS-like tyrosine kinase 3 (FLT3), which may result in the inhibition of tumor cell proliferation and down-modulation of macrophages, osteoclasts and mast cells involved in the osteolytic metastatic disease. FLT3, CSF1R and FLT3 are overexpressed or mutated in many cancer cell types and play major roles in tumor cell proliferation and metastasis.NCI
code
  • C88303
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