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AttributesValues
rdf:type
rdfs:label
  • Volitinib
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Volitinib
PDQ_Open_Trial_Search_ID
  • 745761
PDQ_Closed_Trial_Search_ID
  • 745761
FULL_SYN
  • HMPL-504CNNCI
  • VolitinibPTNCI
DEFINITION
  • An orally bioavailable inhibitor of the c-Met receptor tyrosine kinase with potential antineoplastic activity. Volitinib selectively binds to and inhibits the activation of c-Met in an ATP-competitive manner, and disrupts c-Met signal transduction pathways. This may result in cell growth inhibition in tumors that overexpress the c-Met protein. C-Met encodes the hepatocyte growth factor receptor tyrosine kinase and plays an important role in tumor cell proliferation, survival, invasion, and metastasis, and tumor angiogenesis; this protein is overexpressed or mutated in a variety of cancers.NCI
code
  • C104732
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