About: Telatinib Mesylate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Telatinib Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Telatinib Mesylate
NCI_META_CUI
  • CL415590
PDQ_Open_Trial_Search_ID
  • 652798
PDQ_Closed_Trial_Search_ID
  • 652798
FULL_SYN
  • 17-Demethoxy-17-Allylaminogeldanamycin MesylateSNNCI
  • Telatinib MesylatePTNCI
DEFINITION
  • NCIThe orally bioavailable mesylate salt of the 17-allylaminogeldanamycin (17-AAG) small-molecule inhibitor of several receptor protein tyrosine kinases with potential antiangiogenic and antineoplastic activities. Telatinib binds to and inhibits the vascular endothelial growth factor receptors (VEGFRs) type 2 and 3, platelet-derived growth factor receptor beta (PDGFRb) and c-Kit, which may result in the inhibition of angiogenesis and cellular proliferation in tumors in which these receptors are upregulated. These telatinib-inhibited receptor protein tyrosine kinases are overexpressed or mutated in many tumor cell types and may play key roles in tumor angiogenesis and tumor cell proliferation. 17-AAG is a synthetic analogue of the benzoquinone ansamycin antibiotic geldanamycin and has also been found to inhibit the molecular chaperone Hsp90.
code
  • C87837
is Has_Salt_Form of
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