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AttributesValues
rdf:type
rdfs:label
  • Tivozanib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Tivozanib
UMLS_CUI
  • C2827667
CAS_Registry
  • 475108-18-0
FDA_UNII_Code
  • 172030934T
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 561728
PDQ_Closed_Trial_Search_ID
  • 561728
Chemical_Formula
  • C22H19ClN4O5
FULL_SYN
  • Urea, N-[2-chloro-4-[(6,7-dimethoxy-4-quinolinyl)oxy]phenyl]-N'-(5-methyl-3-isoxazolyl)-SNNCI
  • AV-951CNNCI
  • TIVOZANIBPTFDA172030934T
  • TivozanibPTNCI
DEFINITION
  • An orally bioavailable inhibitor of vascular endothelial growth factor receptors (VEGFRs) 1, 2 and 3 with potential antiangiogenic and antineoplastic activities. Tivozanib binds to and inhibits VEGFRs 1, 2 and 3, which may result in the inhibition of endothelial cell migration and proliferation, inhibition of tumor angiogenesis and tumor cell death. VEGFR tyrosine kinases, frequently overexpressed by a variety of tumor cell types, play a key role in angiogenesis.NCI
code
  • C85444
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