About: Multikinase Inhibitor 4SC-203     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multikinase Inhibitor 4SC-203
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Multikinase Inhibitor 4SC-203
NCI_META_CUI
  • CL416237
PDQ_Open_Trial_Search_ID
  • 666086
PDQ_Closed_Trial_Search_ID
  • 666086
FULL_SYN
  • Multikinase Inhibitor 4SC-203PTNCI
  • 4SC-203CNNCI
DEFINITION
  • A multikinase inhibitor with potential antineoplastic activity. Multikinase inhibitor 4SC-203 selectively inhibits FMS-related tyrosine kinase 3 (FLT3/STK1), FLT3 mutated forms, and vascular endothelial growth factor receptors (VEGFRs). This may result in the inhibition of angiogenesis and cell proliferation in tumor cells in which these kinases are upregulated. FLT3 (FLK2), a class III tyrosine kinase receptor, is overexpressed or mutated in most B lineage and acute myeloid leukemias (AML). VEGFRs, tyrosine kinase receptors, are overexpressed in a variety of tumor cell types and play key roles in angiogenesis.NCI
code
  • C90553
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