About: Tyrosine Kinase Inhibitor SU5402     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tyrosine Kinase Inhibitor SU5402
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tyrosine Kinase Inhibitor SU5402
UMLS_CUI
  • C0538431
Legacy_Concept_Name
  • SU5402
CHEBI_ID
  • CHEBI:63449
FULL_SYN
  • 3-[(3-(2-carboxyethyl)-4-methylpyrrol-2-yl)methylene]-2-indolinoneSNNCI
  • SU 5402CNNCI
  • Tyrosine Kinase Inhibitor SU5402PTNCI
DEFINITION
  • An indolinone-based small molecule selective tyrosine kinase inhibitor with potential antineoplastic activity. SU5402 blocks the activities of vascular endothelial growth factor receptors (VEGFR) and fibroblast growth factor 1 (FGFR1) via competing with ATP for the specific binding site within the catalytic domain of these receptors. This agent was shown to inhibit cell growth, decrease cell viability in dose-dependent manner, and induce apoptosis.NCI
code
  • C1725
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