About: ALK Inhibitor CH5424802     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • ALK Inhibitor CH5424802
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • ALK Inhibitor CH5424802
NCI_META_CUI
  • CL435908
PDQ_Open_Trial_Search_ID
  • 733572
PDQ_Closed_Trial_Search_ID
  • 733572
CHEBI_ID
  • CHEBI:62268
FULL_SYN
  • ALK Inhibitor CH5424802PTNCI
  • AF802CNNCI
  • CH5424802CNNCI
DEFINITION
  • An orally available inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with antineoplastic activity. Upon administration, ALK inhibitor CH542480 binds to and inhibits ALK kinase, ALK fusion proteins as well as the gatekeeper mutation ALKL1196M known as one of the mechanisms of acquired resistance to small-molecule kinase inhibitors. The inhibition leads to disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-overexpressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.NCI
code
  • C101790
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