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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Foretinib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Foretinib
UMLS_CUI
  • C2698272
CAS_Registry
  • 849217-64-7
FDA_UNII_Code
  • 81FH7VK1C4
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. Foretinib blocks enzymes involved in the growth and spread of tumor cells. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 428188
PDQ_Closed_Trial_Search_ID
  • 428188
Chemical_Formula
  • C34H34F2N4O6
Legacy_Concept_Name
  • Multitargeted_Tyrosine_Kinase_Inhibitor_GSK1363089
FULL_SYN
  • N-(3-Fluoro-4-((6-methoxy-7-(3-(morpholin-4-yl)propoxy)quinolin-4-yl)oxy)phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamideSNNCI
  • XL880PTNCI-GLOSSCDR0000549701
  • XL880CNNCI
  • FORETINIBPTFDA81FH7VK1C4
  • Multitargeted Tyrosine Kinase Inhibitor GSK1363089SYNCI
  • ForetinibPTNCI
  • GSK1363089CNNCI
  • MET/VEGFR-2 inhibitor GSK1363089PTNCI-GLOSSCDR0000666675
  • foretinibPTNCI-GLOSSCDR0000675317
DEFINITION
  • An orally bioavailable small molecule with potential antineoplastic activity. Foretinib binds to and selectively inhibits hepatocyte growth factor (HGF) receptor c-MET and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in the inhibition of tumor angiogenesis, tumor cell proliferation and metastasis. The proto-oncogene c-MET has been found to be over-expressed in a variety of cancers. VEGFR2 is found on endothelial and hematopoietic cells and mediates the development of the vasculature and hematopoietic cells through VEGF signaling.NCI
code
  • C80058
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