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AttributesValues
rdf:type
rdfs:label
  • Genistein
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
Preferred_Name
  • Genistein
NSC_Code
  • 36586
UMLS_CUI
  • C0061202
CAS_Registry
  • 446-72-0
In_Clinical_Trial_For
  • Chemoprevention; Localized Prostate Cancer Treated with Radical Prostatectomy; Stage II; III; or IV Prostate Cancer; Major Depression; Cystic Fibrosis.
FDA_UNII_Code
  • DH2M523P0H
Contributing_Source
  • CRCH
  • FDA
ALT_DEFINITION
  • An isoflavone found in soy products. Soy isoflavones are being studied to see if they help prevent cancer.NCI-GLOSS
  • An isoflavone with a hydroxyl group on the B-ring and a second hydroxyl group on the A-ring.CRCH
PDQ_Open_Trial_Search_ID
  • 43214
PDQ_Closed_Trial_Search_ID
  • 43214
Chemical_Formula
  • C15H10O5
INFOODS
  • GNSTEIN
Unit
  • mcg
Legacy_Concept_Name
  • Genistein
CHEBI_ID
  • CHEBI:28088
FULL_SYN
  • GenisteinPTDCP04350
  • 4',5, 7-TrihydroxyisoflavoneSYDTPNSC0036586
  • 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-oneSNNCI
  • 4',5,7-TrihydroxyisoflavoneSNNCI
  • PrunetolSYDTPNSC0036586
  • GENISTEINPTFDADH2M523P0H
  • GenisteinSYDTPNSC0036586
  • GenisteolSYDTPNSC0036586
  • PrunetolSYNCI
  • GenesteinSYNCI
  • GenisteinPTNCI
  • GenisteolSYNCI
  • genisteinPTNCI-GLOSSCDR0000046107
  • GenisteinPTCRCH
DEFINITION
  • A soy-derived isoflavone and phytoestrogen with antineoplastic activity. Genistein binds to and inhibits protein-tyrosine kinase, thereby disrupting signal transduction and inducing cell differentiation. This agent also inhibits topoisomerase-II, leading to DNA fragmentation and apoptosis, and induces G2/M cell cycle arrest. Genistein exhibits antioxidant, antiangiogenic, and immunosuppressive activities. (NCI04)NCI
code
  • C1113
sameAs
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