About: Sunitinib

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About: Sunitinib Goto Sponge NotDistinct Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Sunitinib
rdfs:subClassOf	Tyrosine Kinase Inhibitor Angiogenesis Activator Inhibitor nodeID://b716263 nodeID://b716264 nodeID://b716265 nodeID://b716266 nodeID://b716267
Has_Salt_Form	SUNITINIB MALATE
Has_Target	Receptors, Platelet-Derived Growth Factor Proto-Oncogene Proteins c-kit Vascular Endothelial Growth Factor Receptor-1 Tyrosine-Protein Kinase Receptor RET Fms-Related Tyrosine Kinase 3 Vascular Endothelial Growth Factor Receptor-3 Vascular Endothelial Growth Factor Receptor-2
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Sunitinib
UMLS_CUI	C1176020
CAS_Registry	557795-19-4
FDA_UNII_Code	V99T50803M
Contributing_Source	FDA
ALT_DEFINITION	A drug used to treat gastrointestinal stromal tumors (GIST) that have not responded to treatment with imatinib mesylate (Gleevec). Sunitinib is also used to treat advanced kidney cancer and is being studied in the treatment of other types of cancer. It is a type of tyrosine kinase inhibitor, a type of vascular endothelial growth factor (VEGF) receptor inhibitor, and a type of angiogenesis inhibitor.NCI-GLOSS
Chemical_Formula	C22H27FN4O2
Legacy_Concept_Name	Sunitinib
CHEBI_ID	CHEBI:38940
FULL_SYN	1H-Pyrrole-3-carboxamide, N-(2-(diethylamino)ethyl)-5-((Z)-(5-fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl)-2,4-dimethyl-SNNCI SUNITINIBPTFDAV99T50803M SunitinibPTNCI sunitinibPTNCI-GLOSSCDR0000492233
DEFINITION	An indolinone derivative and tyrosine kinase inhibitor with potential antineoplastic activity. Sunitinib blocks the tyrosine kinase activities of vascular endothelial growth factor receptor 2 (VEGFR2), platelet-derived growth factor receptor b (PDGFRb), and c-kit, thereby inhibiting angiogenesis and cell proliferation. This agent also inhibits the phosphorylation of Fms-related tyrosine kinase 3 (FLT3), another receptor tyrosine kinase expressed by some leukemic cells.NCI
code	C71622
sameAs	SUNITINIB
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0448793
is Has_Free_Acid_Or_Base_Form of	SUNITINIB MALATE
is sameAs of	SUNITINIB SUNITINIB

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