About: Multitargeted Tyrosine Kinase Inhibitor MGCD265     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Multitargeted Tyrosine Kinase Inhibitor MGCD265
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Multitargeted Tyrosine Kinase Inhibitor MGCD265
NCI_META_CUI
  • CL383618
PDQ_Open_Trial_Search_ID
  • 597305
PDQ_Closed_Trial_Search_ID
  • 597305
Legacy_Concept_Name
  • Tyrosine_Kinase_Inhibitor_MGCD265
FULL_SYN
  • TKI MGCD265ABNCI
  • Multitargeted Tyrosine Kinase Inhibitor MGCD265PTNCI
  • MGCD265CNNCI
DEFINITION
  • An orally bioavailable, small-molecule, multitargeted tyrosine kinase inhibitor with potential antineoplastic activity. Multitargeted tyrosine kinase inhibitor MGCD265 binds to and inhibits the phosphorylation of several receptor tyrosine kinases (RTKs), including the c-Met receptor (hepatocyte growth factor receptor); the Tek/Tie-2 receptor; vascular endothelial growth factor receptor (VEGFR) types 1, 2, and 3; and the macrophage-stimulating 1 receptor (MST1R or RON). Inhibition of these RTKs and their downstream signaling pathways may result in the inhibition of tumor angiogenesis and tumor cell proliferation in tumors overexpressing these RTKs.NCI
code
  • C77876
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