About: MEK Inhibitor GDC-0623     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • MEK Inhibitor GDC-0623
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • MEK Inhibitor GDC-0623
NCI_META_CUI
  • CL421583
PDQ_Open_Trial_Search_ID
  • 673612
PDQ_Closed_Trial_Search_ID
  • 673612
FULL_SYN
  • GDC-0623CNNCI
  • MEK Inhibitor GDC-0623PTNCI
DEFINITION
  • An orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers.NCI
code
  • C95738
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