About: pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493
NCI_META_CUI
  • CL438124
PDQ_Open_Trial_Search_ID
  • 741845
PDQ_Closed_Trial_Search_ID
  • 741845
FULL_SYN
  • JNJ-42756493CNNCI
  • pan-FGFR Tyrosine Kinase Inhibitor JNJ-42756493PTNCI
DEFINITION
  • An orally bioavailable, pan fibroblast growth factor receptor (FGFR) inhibitor with potential antineoplastic activity. Upon oral administration, JNJ-42756493 binds to and inhibits FGFR, which may result in the inhibition of FGFR-related signal transduction pathways and thus the inhibition of tumor cell proliferation and tumor cell death in FGFR-overexpressing tumor cells. FGFR, upregulated in many tumor cell types, is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival.NCI
code
  • C103273
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