About: Tandutinib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tandutinib
rdfs:subClassOf	Tyrosine Kinase Inhibitor
Has_Target	Proto-Oncogene Proteins c-kit Fms-Related Tyrosine Kinase 3 Receptor, Platelet-Derived Growth Factor beta
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Tandutinib
NSC_Code	726292
UMLS_CUI	C1143028
CAS_Registry	387867-13-2
FDA_UNII_Code	E1IO3ICJ9A
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. It may stop cancer cell growth by blocking certain enzymes. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	353146
PDQ_Closed_Trial_Search_ID	353146
Chemical_Formula	C31H42N6O4
Legacy_Concept_Name	MLN518
FULL_SYN	tandutinibPTNCI-GLOSSCDR0000528028 MLN518PTNCI-GLOSSCDR0000549427 1-Piperazinecarboxamide, 4-(6-Methoxy-7-(3-(1-piperidinyl)propoxy)-4-quinazolinyl)-N-(4-(1-methylethoxy)phenyl)-SNNCI CT53518PTNCI-GLOSSCDR0000549426 MLN518CNNCI CT53518CNNCI MLN 518CNNCI TANDUTINIBPTFDAE1IO3ICJ9A TandutinibPTNCI
DEFINITION	A piperazinyl quinazoline receptor tyrosine kinase inhibitor with antineoplastic activity. Tandutinib inhibits the autophosphorylation of FLT3 (FMS-Like Tyrosine kinase-3), c-KIT and PDGF (platelet-derived growth factor) receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.NCI
code	C48404
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0437922

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