About: JAK2 Inhibitor AZD1480     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • JAK2 Inhibitor AZD1480
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • JAK2 Inhibitor AZD1480
NCI_META_CUI
  • CL421573
PDQ_Open_Trial_Search_ID
  • 672901
PDQ_Closed_Trial_Search_ID
  • 672901
FULL_SYN
  • AZD1480CNNCI
  • JAK2 Inhibitor AZD1480PTNCI
DEFINITION
  • An orally bioavailable inhibitor of Janus-associated kinase 2 (JAK2) with potential antineoplastic activity. JAK2 inhibitor AZD1480 inhibits JAK2 activation, leading to the inhibition of the JAK/STAT (signal transducer and activator of transcription) signaling including activation of STAT3. This may lead to induction of tumor cell apoptosis and a decrease in cellular proliferation. JAK2, often upregulated or mutated in a variety of cancer cells, mediates STAT3 activation and plays a key role in tumor cell proliferation and survival.NCI
code
  • C91394
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