About: VEGFR/FGFR Dual Kinase Inhibitor E-3810     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • VEGFR/FGFR Dual Kinase Inhibitor E-3810
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • VEGFR/FGFR Dual Kinase Inhibitor E-3810
NCI_META_CUI
  • CL428187
PDQ_Open_Trial_Search_ID
  • 694590
PDQ_Closed_Trial_Search_ID
  • 694590
FULL_SYN
  • E-3810CNNCI
  • VEGFR/FGFR Dual Kinase Inhibitor E-3810PTNCI
DEFINITION
  • A novel dual inhibitor targeting human vascular endothelial growth factor receptors (VEGFRs) and fibroblast growth factor receptors (FGFRs) with antiangiogenic activity. VEGFR/FGFR dual kinase inhibitor E-3810 inhibits VEGFR-1, -2, -3 and FGFR-1, -2 kinases in the nM range, which may result in the inhibition of tumor angiogenesis and tumor cell proliferation, and the induction of tumor cell death. Both VEGFRs and FGFRs belong to the family of receptor tyrosine kinases that may be upregulated in various tumor cell types.NCI
code
  • C95726
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