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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Lestaurtinib
rdfs:subClassOf
Has_Target
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Lestaurtinib
UMLS_CUI
  • C1541677
CAS_Registry
  • 111358-88-4
FDA_UNII_Code
  • DO989GC5D1
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug being studied in the treatment of acute leukemias and some other types of cancer. It binds to a protein that is present on the surface of some types of cancer cells and stops them from dividing. CEP-701 is a type of receptor tyrosine kinase inhibitor and a type of indolocarbazole alkaloid.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 367053
PDQ_Closed_Trial_Search_ID
  • 367053
Chemical_Formula
  • C26H21N3O4
Legacy_Concept_Name
  • Lestaurtinib
FULL_SYN
  • LESTAURTINIBPTFDADO989GC5D1
  • LestaurtinibPTNCI
  • lestaurtinibPTNCI-GLOSSCDR0000559256
  • CEP-701PTNCI-GLOSSCDR0000386200
  • CEP-701CNNCI
  • KT-5555CNNCI
  • SPM-924CNNCI
  • CEP-701PTDCP50524
  • 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocin-1-one, 2,3,9,10,11,12-hexahydro-10-hydroxy-10-(hydroxymethyl)-9-methyl-, (9S,10S,12R)-SNNCI
DEFINITION
  • An orally bioavailable indolocarbazole derivative with antineoplastic properties. Lestaurtinib inhibits autophosphorylation of FMS-like tyrosine kinase 3 (FLT3), resulting in inhibition of FLT3 activity and induction of apoptosis in tumor cells that overexpress FLT3. (NCI05)NCI
code
  • C48402
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