About: Src Kinase Inhibitor KX2-391     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Src Kinase Inhibitor KX2-391
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Src Kinase Inhibitor KX2-391
NCI_META_CUI
  • CL383545
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. KX2-391 blocks an enzyme needed for growth of cells and may kill cancer cells. It is a type of Src kinase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 590687
PDQ_Closed_Trial_Search_ID
  • 590687
Legacy_Concept_Name
  • Src_Kinase_Inhibitor_KX2-391
FULL_SYN
  • KX01CNNCI
  • KX2-391PTNCI-GLOSSCDR0000600441
  • Src Kinase Inhibitor KX2-391PTNCI
  • KX2-391CNNCI
DEFINITION
  • An orally bioavailable small molecule Src kinase inhibitor with potential antineoplastic activity. Unlike other Src kinase inhibitors which bind to the ATP-binding site, Src kinase inhibitor KX2-391 specifically binds to the peptide substrate binding site of Src kinase; inhibition of kinase activity may result in the inhibition of primary tumor growth and the suppression of metastasis. Src tyrosine kinases are upregulated in many tumor cells and play important roles in tumor cell proliferation and metastasis.NCI
code
  • C74077
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