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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Neratinib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Neratinib
UMLS_CUI
  • C1704439
CAS_Registry
  • 698387-09-6
FDA_UNII_Code
  • JJH94R3PWB
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 453548
PDQ_Closed_Trial_Search_ID
  • 453548
Chemical_Formula
  • C30H29ClN6O3
Legacy_Concept_Name
  • KI-272
CHEBI_ID
  • CHEBI:61397
FULL_SYN
  • NERATINIBPTFDAJJH94R3PWB
  • HKI-272CNNCI
  • NeratinibPTNCI
DEFINITION
  • An orally available, 6,7-disubstituted-4-anilinoquinoline-3-carbonitrile irreversible inhibitor of the HER-2 receptor tyrosine kinase with potential antineoplastic activity. Neratinib binds to the HER-2 receptor irreversibly, thereby reducing autophosphorylation in cells, apparently by targeting a cysteine residue in the ATP-binding pocket of the receptor. Treatment of cells with this agent results in inhibition of downstream signal transduction events and cell cycle regulatory pathways; arrest at the G1-S (Gap 1/DNA synthesis)-phase transition of the cell division cycle; and ultimately decreased cellular proliferation. Neratinib also inhibits the epidermal growth factor receptor (EGFR) kinase and the proliferation of EGFR-dependent cells.NCI
code
  • C49094
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