About: BTK Inhibitor ONO-4059     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • BTK Inhibitor ONO-4059
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • BTK Inhibitor ONO-4059
NCI_META_CUI
  • CL437179
PDQ_Open_Trial_Search_ID
  • 738477
PDQ_Closed_Trial_Search_ID
  • 738477
FULL_SYN
  • Bruton's Tyrosine Kinase Inhibitor ONO-4059SYNCI
  • ONO-4059CNNCI
  • BTK Inhibitor ONO-4059PTNCI
DEFINITION
  • An orally available formulation containing an inhibitor of Bruton agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity. Upon administration, ONO-4059 covalently binds to BTK within B cells, thereby preventing B cell receptor signaling and impeding B cell development. As a result, this agent may inhibit the proliferation of B cell malignancies. BTK, a cytoplasmic tyrosine kinase and member of the Tec family of kinases, plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.NCI
code
  • C102876
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