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AttributesValues
rdf:type
rdfs:label
  • Pacritinib
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Pacritinib
NCI_META_CUI
  • CL387719
CAS_Registry
  • 937272-79-2
FDA_UNII_Code
  • G22N65IL3O
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 609888
PDQ_Closed_Trial_Search_ID
  • 609888
Chemical_Formula
  • C28H32N4O3
Legacy_Concept_Name
  • JAK2_Inhibitor_SB1518
FULL_SYN
  • Oral JAK2 Inhibitor SB1518SYNCI
  • SB1518CNNCI
  • PACRITINIBPTFDAG22N65IL3O
  • PacritinibPTNCI
DEFINITION
  • An orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Oral JAK2 inhibitor SB1518 competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis. JAK2 is the most common mutated gene in bcr-abl-negative myeloproliferative disorders; the JAK2V617F gain-of-function mutation involves a valine-to-phenylalanine modification at position 617. The JAK-STAT signaling pathway is a major mediator of cytokine activity.NCI
code
  • C78837
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