About: cFMS Tyrosine Kinase Inhibitor ARRY-382     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • cFMS Tyrosine Kinase Inhibitor ARRY-382
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • cFMS Tyrosine Kinase Inhibitor ARRY-382
NCI_META_CUI
  • CL429011
PDQ_Open_Trial_Search_ID
  • 697525
PDQ_Closed_Trial_Search_ID
  • 697525
FULL_SYN
  • cFMS Tyrosine Kinase Inhibitor ARRY-382PTNCI
  • ARRY-382CNNCI
DEFINITION
  • A small molecule and orally available inhibitor of colony-stimulating factor-1 receptor (CSF1R; cFMS) with potential antineoplastic activity. cFMS tyrosine kinase inhibitor ARRY-382 binds to and inhibits the activity of cFMS. By preventing colony-stimulating factor-1 (CSF-1)-cFMS signaling, this agent may inhibit tumor cell proliferation in cFMS-overexpressing tumor cells. cFMS, a tyrosine kinase receptor, is overexpressed in certain tumor cell types and plays an essential role in macrophage differentiation and regulation of cell proliferation.NCI
code
  • C96227
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