About: Crizotinib

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Crizotinib
rdfs:subClassOf	Tyrosine Kinase Inhibitor nodeID://b689720
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance
Preferred_Name	Crizotinib
UMLS_CUI	C1957666
CAS_Registry	877399-52-5
Accepted_Therapeutic_Use_For	Non-Small Cell Lung Cancer
FDA_UNII_Code	53AH36668S
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of some types of cancer. It blocks enzymes that cancer cells need to grow and spread. It may also prevent the growth of new blood vessels that tumors need to grow. It is a type of tyrosine kinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	586080
PDQ_Closed_Trial_Search_ID	586080
Chemical_Formula	C21H22Cl2FN5O
Legacy_Concept_Name	MET_Tyrosine_Kinase_Inhibitor_PF-02341066
CHEBI_ID	CHEBI:64310
FULL_SYN	(R)-3-(1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(Piperidin-4-Yl)-1h-Pyrazol-4-Yl)Pyridin-2-AmineSNNCI MET tyrosine kinase inhibitor PF-02341066PTNCI-GLOSSCDR0000658849 2-Pyridinamine, 3-((1R)-1-(2,6-Dichloro-3-Fluorophenyl)Ethoxy)-5-(1-(4-Piperidinyl)-1H-Pyrazol-4-yl)-SNNCI XalkoriBRNCI CRIZOTINIBPTFDA53AH36668S MET Tyrosine Kinase Inhibitor PF-02341066SYNCI PF-2341066CNNCI PF-02341066PTNCI-GLOSSCDR0000658850 CrizotinibPTNCI
DEFINITION	An orally available aminopyridine-based inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) and the c-Met/hepatocyte growth factor receptor (HGFR) with antineoplastic activity. Crizotinib, in an ATP-competitive manner, binds to and inhibits ALK kinase and ALK fusion proteins. In addition, crizotinib inhibits c-Met kinase, and disrupts the c-Met signaling pathway. Altogether, this agent inhibits tumor cell growth. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development. ALK dysregulation and gene rearrangements are associated with a series of tumors.NCI
code	C74061
sameAs	Crizotinib
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0510573
is sameAs of	Crizotinib

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