About: Vinca-Domain Binding Agent

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vinca-Domain Binding Agent
rdfs:subClassOf	Tubulin Binding Agent
Semantic_Type	Chemical Viewed Functionally
Preferred_Name	Vinca-Domain Binding Agent
UMLS_CUI	C1883533
Legacy_Concept_Name	Vinca-Site_Binding_Agent
FULL_SYN	Vinca-Site Binding AgentSYNCI Vinca-Site Binding AgentsSYNCI Vinca-Domain Binding AgentPTNCI Vinca-Domain Binding AgentsSYNCI
DEFINITION	Any of a class of anti-mitotic compounds that bind to the vinca site of the beta tubulin subunit, a region located within the middle domain of the tubulin structure and corresponding with a residue sequence approximating 177-215. The agent binds to the vinca site to produce a conformational change in the protofilament structure and at high concentrations, to induce the formation of spirals and crystal aggregates; these changes impair the polymerization of tubulin dimers and thereby, prevent the assembly of microtubules. The subsequent decrease in the amount of formed microtubules causes disassembly of the mitotic spindle resulting from instability of the structure during the mitotic interphase, eventually leading to cell cycle arrest and/or apoptosis. Vinca-site binding agents include natural compounds isolated from the periwinkle (Catharanthus roseus, formally, Vinca roseus) plant and synthetic compounds.NCI
code	C67422
is rdfs:subClassOf of	Vinepidine Spongistatin Vincristine Liposomal Vinflunine Liposomal Vinorelbine Vinorelbine Tartrate Emulsion Vinflunine Ditartrate Thalicarpine VINORELBINE Vinzolidine Dolastatin 10 Halichondrin B VINORELBINE TARTRATE Dolastatin 15 Cryptophycin Cemadotin Hydrochloride Vincristine Sulfate Cryptophycin 52 Dolastatin 9 Vinfosiltine Anhydrovinblastine ERIBULIN MESYLATE Soblidotin Vincristine Sulfate Liposome Hemiasterlin Analog E7974 TTI-237 Vintafolide Cemadotin Vinorelbine Tartrate Oral Vinzolidine Sulfate VINBLASTINE Vinblastine Sulfate VINCRISTINE VINDESINE Vindesine Sulfate ERIBULIN

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