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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Vinfosiltine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Vinfosiltine
UMLS_CUI
  • C0084429
CAS_Registry
  • 123286-00-0
FDA_UNII_Code
  • AW1UYE6Q9I
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 41716
PDQ_Closed_Trial_Search_ID
  • 41716
Chemical_Formula
  • C51H72N5O10P
Legacy_Concept_Name
  • Vinfosiltine
FULL_SYN
  • VINFOSILTINEPTFDAAW1UYE6Q9I
  • VinfosiltinePTNCI
  • S12363CNNCI
  • Vincaleukoblastine, O4-Deacetyl-3-de(methoxycarbonyl)-3-(((1-(diethoxyphosphinyl)-2-methylpropyl)amin)carbonyl)-,(3(S))-,Sulfate(Salt)SNNCI
DEFINITION
  • An aminophosphonate derivative of a vinca alkaloid with potential antineoplastic activity. Vinfosiltine exerts its antineoplastic action just like its parent compound, vinblastine, by immobilizing tubulin molecules, thereby interrupting microtubule assembly/disassembly dynamics. As a result, vinfosiltine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.NCI
code
  • C2378
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