About: Eribulin Mesylate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Eribulin Mesylate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Eribulin Mesylate
NSC_Code
  • 707389
UMLS_CUI
  • C2608038
CAS_Registry
  • 253128-41-5
Accepted_Therapeutic_Use_For
  • Breast Cancer
In_Clinical_Trial_For
  • Non-Small Cell Lung Cancer and Advanced Solid Tumors.
FDA_UNII_Code
  • AV9U0660CW
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitubulin agents.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 257773
PDQ_Closed_Trial_Search_ID
  • 257773
Chemical_Formula
  • C40H59NO11.CH4O3S
Legacy_Concept_Name
  • E7389
FULL_SYN
  • 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-oneSNNCI
  • E7389PTNCI-GLOSSCDR0000285632
  • E7389CNNCI
  • Eribulin MesylatePTNCI
  • ERIBULIN MESYLATEPTFDAAV9U0660CW
  • HalavenBRNCI
  • ER-086526CNNCI
  • Halichondrin B AnalogSYNCI
DEFINITION
  • The mesylate salt of a synthetic analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.NCI
code
  • C26644
sameAs
is Has_Salt_Form of
is sameAs of
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