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AttributesValues
rdf:type
rdfs:label
  • Eribulin
rdfs:subClassOf
Has_Salt_Form
Has_Target
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Eribulin
UMLS_CUI
  • C2350866
CAS_Registry
  • 253128-41-5
Accepted_Therapeutic_Use_For
  • Breast Cancer
FDA_UNII_Code
  • LR24G6354G
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called antitubulin agents.NCI-GLOSS
Chemical_Formula
  • C40H59NO11
CHEBI_ID
  • CHEBI:63587
FULL_SYN
  • 2-(3-Amino-2-hydroxypropyl)hexacosahydro-3-methoxy-26-methyl-20,27-bis(methylene)11,15-18,21-24,28-triepoxy-7,9-ethano-12,15-methano-9H,15H-furo(3,2-i)furo(2',3'-5,6)pyrano(4,3-b)(1,4)dioxacyclopentacosin-5-(4H)-oneSNNCI
  • ERIBULINPTFDALR24G6354G
  • EribulinPTNCI
  • ER-086526CNNCI
DEFINITION
  • An analogue of halichondrin B, a substance derived from a marine sponge (Lissodendoryx sp.) with antineoplastic activity. Eribulin binds to the vinca domain of tubulin and inhibits the polymerization of tubulin and the assembly of microtubules, resulting in inhibition of mitotic spindle assembly, induction of cell cycle arrest at G2/M phase, and, potentially, tumor regression.NCI
code
  • C96748
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