About: Tubulin

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Tubulin
rdfs:subClassOf	Cytoskeletal Proteins nodeID://b721204
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Tubulin
UMLS_CUI	C0041348
ALT_DEFINITION	One of a group of proteins found in high levels in the cell cytoplasm (fluid inside a cell but outside the cell's nucleus). Tubulins are the building blocks of microtubules (narrow, hollow tubes inside a cell), which are involved in cell division and cell movement. Certain anticancer drugs bind to and block the formation or function of tubulins, which may block cell division.NCI-GLOSS globular subunit of microtubules, whose ATP- and GTP-dependent polymerization and depolymerization is the basis for many intracellular movement functions.CSP2000 A microtubule subunit protein found in large quantities in mammalian brain. It has also been isolated from sperm flagella, cilia, and other sources. Structurally, the protein is a dimer with a molecular weight of approximately 120,000 and a sedimentation coefficient of 5.8S. It binds to colchicine, vincristine, and vinblastine.MSH2001
Legacy_Concept_Name	Tubulin
FULL_SYN	tubulinPTNCI-GLOSSCDR0000597173 TubulinPTNCI
DEFINITION	Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. (from LocusLink)NCI
code	C17219
sameAs	Tubulin
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0022142
is rdf:first of	nodeID://b731304 nodeID://b731305 nodeID://b731306
is rdfs:subClassOf of	Gamma-Tubulin
is someValuesFrom of	nodeID://b650131 nodeID://b667058 nodeID://b667231 nodeID://b668252 nodeID://b668285 nodeID://b669012 nodeID://b670726 nodeID://b674300 nodeID://b676311 nodeID://b676340 nodeID://b676343 nodeID://b684420 nodeID://b684465 nodeID://b691082 nodeID://b693382 nodeID://b698183 nodeID://b701469 nodeID://b701476 nodeID://b709124 nodeID://b718729 nodeID://b722944 nodeID://b723840
is Has_Target of	Paclitaxel Liposome Plinabulin 14C BMS-275183 Liposomal Vinorelbine Pegylated Paclitaxel Verubulin Hydrochloride Vinorelbine Tartrate Emulsion 2-Methoxyestradiol Paclitaxel Ceribate PACLITAXEL DOCETAXEL Benzoylphenylurea ERIBULIN MESYLATE Vincristine Sulfate Liposome IXABEPILONE TTI-237 Vintafolide 2-Methoxyestradiol Nanocrystal Colloidal Dispersion Oral Ixabepilone CABAZITAXEL Crolibulin Folate Receptor-Targeted Vinca Alkaloid EC0489 Verubulin ERIBULIN Iso-fludelone
is sameAs of	Tubulin

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