About: Vinorelbine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vinorelbine
rdfs:subClassOf	Vinca-Domain Binding Agent Vinca Alkaloids
Has_Salt_Form	VINORELBINE TARTRATE
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vinorelbine
UMLS_CUI	C0078257
CAS_Registry	71486-22-1
Accepted_Therapeutic_Use_For	Breast cancer; Cervical cancer; Non-small cell lung cancer; Ovarian cancer; Prostate cancer
In_Clinical_Trial_For	Brain metastases; Breast cancer; Cervical cancer; Hodgkins lymphoma; Mesothelioma; Non-small cell lung cancer; Solid tumors, childhood
FDA_UNII_Code	Q6C979R91Y
Contributing_Source	FDA
ALT_DEFINITION	An anticancer drug that belongs to the family of plant drugs called vinca alkaloids.NCI-GLOSS
Chemical_Formula	C45H54N4O8
Legacy_Concept_Name	Vinorelbine
CHEBI_ID	CHEBI:480999
FULL_SYN	VinorelbinePTNCI vinorelbinePTNCI-GLOSSCDR0000045299 5'-Nor-AnhydrovinblastineSNNCI nor-5'-AnhydrovinblastineSNNCI DihydroxydeoxynorvinkaleukoblastineSYNCI 3',4'-Didehydro-4'-deoxy-C'-norvincaleukoblastineSNNCI VINORELBINEPTFDAQ6C979R91Y
DEFINITION	A semisynthetic vinca alkaloid. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in the arrest of tumor cell growth in metaphase. This agent may also interfere with amino acid, cyclic AMP. and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.NCI
code	C1275
sameAs	VINORELBINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0097344
is someValuesFrom of	nodeID://b650360 nodeID://b650367 nodeID://b656659 nodeID://b657348 nodeID://b658267 nodeID://b660397 nodeID://b660485 nodeID://b660509 nodeID://b660539 nodeID://b660550 nodeID://b660559 nodeID://b660575 nodeID://b667135 nodeID://b667139 nodeID://b667208 nodeID://b667344 nodeID://b667458 nodeID://b667515 nodeID://b667730 nodeID://b670559 nodeID://b670975 nodeID://b670979 nodeID://b670987 nodeID://b674156 nodeID://b676668 nodeID://b676728 nodeID://b682142 nodeID://b682170 nodeID://b686236 nodeID://b693378 nodeID://b700021 nodeID://b701509 nodeID://b709419 nodeID://b719021 nodeID://b720950 nodeID://b723010 nodeID://b723012 nodeID://b723015 nodeID://b723021 nodeID://b723022
is Has_Free_Acid_Or_Base_Form of	VINORELBINE TARTRATE
is sameAs of	VINORELBINE VINORELBINE

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