About: Vinorelbine Tartrate     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Vinorelbine Tartrate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Vinorelbine Tartrate
NSC_Code
  • 608210
UMLS_CUI
  • C0377401
CAS_Registry
  • 125317-39-7
Accepted_Therapeutic_Use_For
  • Non-small cell lung cancer; metastatic breast cancer; uterine and cervical cancer; desmoid tumors; advanced Kaposi's sarcoma
In_Clinical_Trial_For
  • Malignant pleural mesothelioma; advanced non-small cell lung cancer; recurrent brain metastases; recurrent or refractory Hodgkins lymphoma
  • Early stage breast cancer, metastatic breast cancer, Stage IIIA, IIIB, or IV non-small cell lung cancer, Stage IVB, recurrent, or persistent carcinoma of the cervix
FDA_UNII_Code
  • 253GQW851Q
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat advanced non-small cell lung cancer. It blocks cell growth by stopping cell division and may cause cancer cells to die. It is a type of vinca alkaloid and a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 40449
PDQ_Closed_Trial_Search_ID
  • 40449
Chemical_Formula
  • C45H54N4O8.2C4H6O6
Legacy_Concept_Name
  • Vinorelbine_Ditartrate
CHEBI_ID
  • CHEBI:32296
FULL_SYN
  • VINORELBINE TARTRATEPTFDA253GQW851Q
  • Vinorelbine DitartrateSYNCI
  • Navelbine ditartrateSYDTPNSC0608210
  • NVBABNCI
  • vinorelbine tartratePTNCI-GLOSSCDR0000658039
  • KW-2307CNNCI
  • EunadesFBNCI
  • Navelbine DitartrateSYNCI
  • Vinorelbine TartratePTNCI
  • NavelbineBRNCI
  • BiovelbinFBNCI
  • NavelbinePTNCI-GLOSSCDR0000658040
DEFINITION
  • The ditartrate salt of a semisynthetic vinca alkaloid derived from the leaves of the periwinkle plant (Vinca rosea) with antineoplastic properties. Vinorelbine binds to tubulin, thereby inhibiting tubulin polymerization into microtubules and spindle formation and resulting in apoptosis of susceptible cancer cells. Inhibition of mitotic microtubules correlates with antitumor activity, whereas inhibition of axonal microtubules seems to correlate with vinorelbine's neurotoxicity. Compared to related vinca alkaloids, vinorelbine is more selective against mitotic than axonal microtubules in vitro, which may account for its decreased neurotoxicity. This agent is also a radiation-sensitizing agent. (NCI04)NCI
code
  • C1395
sameAs
http://linked.open...y/mesh/hasConcept
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