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AttributesValues
rdf:type
rdfs:label
  • Liposomal Vinorelbine
rdfs:subClassOf
Has_Target
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Liposomal Vinorelbine
UMLS_CUI
  • C1831959
PDQ_Open_Trial_Search_ID
  • 507579
PDQ_Closed_Trial_Search_ID
  • 507579
Legacy_Concept_Name
  • Liposomal_Vinorelbine
FULL_SYN
  • Liposomal VinorelbinePTNCI
DEFINITION
  • A formulation of the semisynthetic vinca alkaloid, vinorelbine, encapsulated within liposomes, with antineoplastic activity. Vinorelbine binds to tubulin and prevents formation of the mitotic spindle, resulting in cell cycle arrest in metaphase. Like other vinca alkaloids, vinorelbine may also interfere with the metabolism of nucleic acids, lipids, amino acids, cAMP, and glutathione, as well as other biological processes including calmodulin-dependent Ca2+-transport, ATPase activity, or cellular respiration. Liposomal delivery of vinorelbine improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic effects while lowering the toxicity profile.NCI
code
  • C62790
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