About: Vinorelbine Tartrate Emulsion     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Vinorelbine Tartrate Emulsion
rdfs:subClassOf
Has_Target
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vinorelbine Tartrate Emulsion
UMLS_CUI
  • C1883539
In_Clinical_Trial_For
  • Advanced Cancer
PDQ_Open_Trial_Search_ID
  • 538399
PDQ_Closed_Trial_Search_ID
  • 538399
Legacy_Concept_Name
  • Vinorelbine_Tartrate_Emulsion
FULL_SYN
  • ANX-530CNNCI
  • Vinorelbine Tartrate EmulsionPTNCI
  • Vinorelbine Tartrate Injectable EmulsionSYNCI
DEFINITION
  • An emulsion containing the tartrate salt of the semisynthetic vinca alkaloid vinorelbine with antineoplastic activity. Vinorelbine binds to tubulin, inhibiting tubulin polymerization into microtubules; cell division is prevented, the cell cycle is arrested metaphase and cell death ensues. In this formulation vinorelbine is emulsified in a homogeneous suspension of nanoparticles, which protects the venous endothelium from coming into direct contact with the active ingredient, potentially reducing vinorelbine-associated venous toxicity at the venous injection site.NCI
code
  • C66943
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