About: Dolastatin 15     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Dolastatin 15
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Dolastatin 15
NSC_Code
  • 617668
UMLS_CUI
  • C0170214
CAS_Registry
  • 123884-00-4
Legacy_Concept_Name
  • Dolastatin_15
FULL_SYN
  • Dolastatin 15SYDTPNSC0617668
  • Dolastatin 15PTNCI
  • L-proline,1-(1-(N-(N-(N,N-dimethyl-L-valyl)-L-valyl)-N-methyl-L-valyl)-L-prolyl-.1-((2,5-dihydro-3-methoxy-5-oxo-2-(phenylmethyl)-1H-pyrrol-1-yl)carbonyl)-2-methylpropyl ester, (S-(R*,R*))SNNCI
DEFINITION
  • A depsipeptide originally isolated from the marine mollusk Dolabella auricularia with potential antineoplastic activity. Less potent than the structurally-related compound dolastatin 10, dolastatin 15 binds weakly to tubulin and blocks microtubule assembly, thereby inhibiting mitosis. Dolastatin 15 also induces tumor cell apoptosis through a mechanism involving bcl-2, an oncoprotein that is overexpressed in some cancers. (NCI04)NCI
code
  • C1439
http://linked.open...y/mesh/hasConcept
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