About: Vincristine Sulfate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Vincristine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Vincristine Sulfate
NSC_Code
  • 67574
UMLS_CUI
  • C0591904
CAS_Registry
  • 2068-78-2
Accepted_Therapeutic_Use_For
  • Acute Lymphoblastic Leukemia; Acute Myeloid Leukemia; Neuroblastoma
FDA_UNII_Code
  • T5IRO3534A
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat acute leukemia. It is used in combination with other drugs to treat Hodgkin disease, non-Hodgkin lymphoma, rhabdomyosarcoma, neuroblastoma, and Wilms tumor. Oncovin is also being studied in the treatment of other types of cancer. It blocks cell growth by stopping cell division. It is a type of vinca alkaloid and a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42251
PDQ_Closed_Trial_Search_ID
  • 42251
Chemical_Formula
  • C46H56N4O10.H2O4S
Legacy_Concept_Name
  • Vincristine_Sulfate
FULL_SYN
  • KyocristineSYDTPNSC0067574
  • KyocristineFBNCI
  • Vincristine, sulfateSYDTPNSC0067574
  • vincristine sulfatePTNCI-GLOSSCDR0000615324
  • Leurocristine sulfateSYDTPNSC0067574
  • OncovinSYDTPNSC0067574
  • Leurocristine, sulfateSYDTPNSC0067574
  • OncovinPTNCI-GLOSSCDR0000615325
  • OncovinBRNCI
  • VincrexBRNCI
  • Vincristine SulfatePTNCI
  • VincasarFBNCI
  • VincosidBRNCI
  • VINCRISTINE SULFATEPTFDAT5IRO3534A
  • VINCRISTINE SULFATESYDTPNSC0067574
  • Leurocristine SulfateSYNCI
DEFINITION
  • The sulfate salt of a natural alkaloid isolated from the plant Catharanthus roseus (Vinca rosea L.) with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca(2+)-activated ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis.NCI
code
  • C1739
sameAs
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is someValuesFrom of
is Has_Salt_Form of
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