About: Vincristine Sulfate Liposome

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Attributes	Values
rdf:type	Class
rdfs:label	Vincristine Sulfate Liposome
rdfs:subClassOf	Vinca-Domain Binding Agent Vinca Alkaloids nodeID://b722993 nodeID://b722994 nodeID://b722995
Has_Target	Tubulin
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vincristine Sulfate Liposome
UMLS_CUI	C0935690
Accepted_Therapeutic_Use_For	acute lymphoblastic leukemia (ALL)
PDQ_Open_Trial_Search_ID	38100
PDQ_Closed_Trial_Search_ID	38100
Legacy_Concept_Name	Vincristine_Sulfate_Liposomes
FULL_SYN	Vincristine Sulfate LiposomePTNCI MarqiboBRNCI
DEFINITION	A sphingomyelin/cholesterol liposomal formulation of vincristine sulfate with potential antineoplastic activity. Vincristine, a vinca alkaloid isolated from the plant Vinca rosea, irreversibly binds to and stabilizes tubulin, thereby interrupting microtubule assembly/disassembly dynamics, thereby preventing the formation of the mitotic spindle and leading to cell cycle arrest in metaphase. Liposomal encapsulation prolongs bioavailability of vincristine, increases its delivery to tumor tissues and reduces its toxicity profile. Compared to standard liposomal delivery, sphingosomal drug delivery further increases circulation time of serum drug and enhances drug accumulation at tumor sites, thereby leading to a further increase in efficacy.NCI
code	C2702

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