About: Vinzolidine Sulfate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Vinzolidine Sulfate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Vinzolidine Sulfate
UMLS_CUI
  • C2828244
CAS_Registry
  • 67699-41-6
FDA_UNII_Code
  • 78NZ2PMP25
Contributing_Source
  • FDA
Chemical_Formula
  • C48H58ClN5O9.H2O4S
FULL_SYN
  • Methyl (3R,5S,7R,9S)-9-[3'-(2-Chloroethyl)-6,7-Didehydro-4.Beta.-Hydroxy-16-Methoxy-1-Methyl-2',4'-Dioxo-2.Beta.,3.Beta.,5.Alpha.,12.Beta.,19.Alpha.-Spiro(Aspidospermidine-3,5'-Oxazolidin]-15-yl)-5-Ethyl-1,4,5,6,7,8,9,10-Octahydro-5-Hydroxy-2H-3,7-MethanoSNNCI
  • LY104208CNNCI
  • Vinzolidine SulfatePTNCI
  • 2h-3,7-Methanoazacycloundecino(5,4-.Beta.)Indole-9-Carboxylic Acid, 9-((2.Beta.,3.Beta,4.Beta.,5.Alpha.,12.Beta.,19.Alpha.)-4-(Acetyloxy)-3'-(2-Chloroethyl)-6,7-Didehydro-16-Methoxy-1-Methyl-2',4'-Dioxospiro(Aspidospermidine-3,5'-Oxazolidin)-15-Yl)-5-EthySNNCI
  • VINZOLIDINE SULFATEPTFDA78NZ2PMP25
DEFINITION
  • The sulfate salt of vinzolidine, an orally active semisynthetic vinca alkaloid with potential antineoplastic activity. Like other vinca alkaloid compounds, vinzolidine binds to and stabilizes tubulin molecules, thereby interfering with microtubule assembly/disassembly dynamics. As a result, vinzolidine prevents mitotic spindle formation and leads to cell cycle arrest in metaphase.NCI
code
  • C87288
is Has_Salt_Form of
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