About: Cryptophycin     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cryptophycin
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Antibiotic
Preferred_Name
  • Cryptophycin
NSC_Code
  • 667642
UMLS_CUI
  • C0257217
CAS_Registry
  • 124689-65-2
Legacy_Concept_Name
  • Cryptophycin
FULL_SYN
  • CryptophycinSYDTPNSC0667642
  • CryptophycinPTNCI
  • Cryptophycin 1SYNCI
  • CryptophycinPTDCP50527
  • 10-((3-Chloro-4-methoxyphenyl)methyl)-6-methyl-3-(2-methylpropyl)-16-(1-(3-phenyloxiranyl)ethyl)-1,4-dioxa-8,11-diazacyclohexadec-13-ene-2,5,9,12-tetroneSNNCI
DEFINITION
  • The cryptophycins are a family of 16-membered macrolide antimitotic agents isolated from the cyanobacteria Nostoc sp. The mechanism of anticancer activity of the cryptophycins has been associated with their destabilization of microtubules and induction of bcl-2 phosphorylation leading to apoptosis. Cryptophycins demonstrated activity against the wide spectrum of solid tumors including those that overexpress the multidrug resistance efflux pump P-glycoprotein. (NCI)NCI
code
  • C1546
http://linked.open...y/mesh/hasConcept
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