About: Vinblastine

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Vinblastine
rdfs:subClassOf	Vinca-Domain Binding Agent Vinca Alkaloids nodeID://b722980
Has_Salt_Form	Vinblastine Sulfate
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Vinblastine
NSC_Code	90636
UMLS_CUI	C0042670
CAS_Registry	865-21-4
Accepted_Therapeutic_Use_For	Bladder cancer; Breast cancer; Choriocarcinoma; Germ cell tumors; Idiopathic thrombocytopenic purpura; Kaposi sarcoma; Letterer-Siwe disease; Various Lymphomas; Melanoma; Mycosis fungoides; Prostate cancer; Testicular cancer
In_Clinical_Trial_For	Bladder cancer; Childhood neurofibrosarcoma; Childhood soft tissue sarcoma; Extragonadal germ cell tumor; Hodgkins lymphoma; Melanoma; Non-small cell lung cancer; Prostate cancer; Testicular cancer; Urethral cancer
FDA_UNII_Code	5V9KLZ54CY
Contributing_Source	FDA
ALT_DEFINITION	The active ingredient in a drug used together with other drugs to treat several types of cancer, including advanced Hodgkin lymphoma and advanced testicular germinal-cell cancers. It is also being studied in the treatment of other types of cancer. Vinblastine comes from the periwinkle plant Vinca rosea Linn. It blocks cell growth by stopping cell division and may kill cancer cells. It is a type of vinca alkaloid and a type of antimitotic agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42951
PDQ_Closed_Trial_Search_ID	42951
Chemical_Formula	C46H58N4O9
Legacy_Concept_Name	Vinblastine
CHEBI_ID	CHEBI:27375
FULL_SYN	VinblastinePTNCI vinblastinePTNCI-GLOSSCDR0000045895 VLBABNCI VincaleucoblastineSYNCI VINBLASTINEPTFDA5V9KLZ54CY
DEFINITION	A natural alkaloid isolated from the plant Vinca rosea Linn. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle. This agent may also interfere with amino acid, cyclic AMP, and glutathione metabolism; calmodulin-dependent Ca++ -transport ATPase activity; cellular respiration; and nucleic acid and lipid biosynthesis. (NCI04)NCI
code	C930
sameAs	VINBLASTINE
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0022672
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