| Attributes | Values |
|---|
| rdf:type
| |
| rdfs:seeAlso
| |
| Description
| - Aim of this project is to study in model organisms the functions of genes that have terapeutical and biotechnological potential. We will focus on orthologues of human genes, the products of which have been associated with serious diseases. Since for ethical reasons, functional studies in humans are virtually impossible and many analyses in related mammals are cost prohibitive and/or limited by a number of factors, the role of model organisms in the study of complex human diseases is quickly growing. In frame of this project we want to dissect the functions of selected proteins in model organisms Trypanosoma brucei, Caenorhabditis elegans and Drosophila melanogaster. Using cutting edge methods of genetic manipulation (RNA interference, knock-in, complementation etc.) we will particularly concentrate on functional analysis of i/ proteins involved in iron-sulfur cluster synthesis (e.g. frataxin), ii/ nuclear receptors (e.g. NHR-25), iii/ transcriptional cofactors (e.g. MBF1) and iv/ proto-oncoproteins (en)
- Cílem předkládaného projektu je funkční analýza genů modelových organismů, které mají terapeutický a/nebo biotechnologický potenciál. Zaměříme se na ortology lidských genů, jejichž produkty mohou způsobovat závažné lidské choroby. Funkční analýzy těchtogenů však nejsou z etických důvodů u člověka realizovatelné a jejich provádění u příbuzných savců je nejen velmi drahé, ale je rovněž limitováno řadou faktorů. Z těchto důvodů silně narůstá význam modelových organismů při studiu složitých lidských chorob.V rámci tohoto projektu chceme charakterizovat funkce vybraných proteinů u modelových organismů Trypanosoma brucei, Caenorhabditis elegans a Drosophila melanogaster. Za použití nejmodernějších přístupů genetických manipulací (interference RNA, vklánání genů metodou %22knock-in%22, komplementací apod.) se zaměříme zejména na funkční analýzu: i/ proteinů účastnících syntézy železosirných klasterů (např. frataxin), ii/ jaderných receptorů (např. NHR-25), iii/ transkripčních kofaktorů (např. MBF1) a iv/ prot
|
| Title
| - Model organisms as a key to the understanding of functions of disease-related human genes (en)
- MODELOVÉ ORGANISMY JAKO KLÍČ K POCHOPENÍ FUNKCE GENŮ NEZBYTNÝCH PRO ZDRAVÍ ČLOVĚKA
|
| skos:notation
| |
| http://linked.open...avai/cep/aktivita
| |
| http://linked.open...kovaStatniPodpora
| |
| http://linked.open...ep/celkoveNaklady
| |
| http://linked.open...datumDodatniDoRIV
| |
| http://linked.open...i/cep/druhSouteze
| |
| http://linked.open...ep/duvernostUdaju
| |
| http://linked.open.../cep/fazeProjektu
| |
| http://linked.open...ai/cep/hlavniObor
| |
| http://linked.open...hodnoceniProjektu
| |
| http://linked.open...vai/cep/kategorie
| |
| http://linked.open.../cep/klicovaSlova
| - Frataxin, železosirná centra, Trypanosoma, Leishmania, transkripční faktor, drosofila, Caenorhabditis, onkogen, jaderný receptor, RNA interference (en)
|
| http://linked.open...ep/partnetrHlavni
| |
| http://linked.open...inujicichPrijemcu
| |
| http://linked.open...cep/pocetPrijemcu
| |
| http://linked.open...ocetSpoluPrijemcu
| |
| http://linked.open.../pocetVysledkuRIV
| |
| http://linked.open...enychVysledkuVRIV
| |
| http://linked.open...lneniVMinulemRoce
| |
| http://linked.open.../prideleniPodpory
| |
| http://linked.open...iciPoslednihoRoku
| |
| http://linked.open...atUdajeProjZameru
| |
| http://linked.open.../vavai/cep/soutez
| |
| http://linked.open...usZobrazovaneFaze
| |
| http://linked.open...ai/cep/typPojektu
| |
| http://linked.open...ep/ukonceniReseni
| |
| http://linked.open.../cep/vedlejsiObor
| |
| http://linked.open...ep/zahajeniReseni
| |
| http://linked.open...jektu+dodavatelem
| - Během řešení tohoto projektu bylo dosaženo vynikajících originálních výsledků, které byly publikovány v nejlepších světových časopisech. Bylo popsáno několik základních molekulárních mechanizmů na modelových organizmech, které zcela jistě výrazně přispívají k našim současným znalostem. (cs)
- This project shows undoubtedly excellent results that were published in world leading journals. Several molecular mechanisms have been described in model organisms for the first time and significantly contributed to our current knowledge. (en)
|
| http://linked.open...tniCyklusProjektu
| |
| http://linked.open.../cep/klicoveSlovo
| - Leishmania
- Caenorhabditis
- Trypanosoma
- drosofila
- jaderný receptor
- onkogen
- transkripční faktor
- železosirná centra
- Frataxin
|
| is http://linked.open...vavai/riv/projekt
of | - Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell
- Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors
- Experimental Examination of EFL and MATX Eukaryotic Horizontal Gene Transfers: Coexistence of Mutually Exclusive Transcripts Predates Functional Rescue
- Morphology and Ultrastructure of Multiple Life Cycle Stages of the Photosynthetic Relative of Apicomplexa, Chromera velia
- MRB3010 is a core component of the MRB1 complex that facilitates an early step of the kinetoplastid RNA editing process
- Stage-specific requirement for Isa1 and Isa2 proteins in the mitochondrion of Trypanosoma brucei and heterologous rescue by human and Blastocystis orthologues
- Complex I (NADH:ubiquinone oxidoreductase) is active in but non-essential for procyclic Trypanosoma brucei
- DEAD-box RNA helicase is dispensable for mitochondrial translation in Trypanosoma brucei
- Morphology, Ultrastructure and Life Cycle of Vitrella brassicaformis n. sp., n. gen., a Novel Chromerid from the Great Barrier Reef
- Morphological discordance of the new trypanosomatid species phylogenetically associated with the genus Crithidia
- Dynamism in physiology and gene transcription during reproductive diapause in a heteropteran bug, Pyrrhocoris apterus
- A diagnostic assay based on variable intergenic region distinguishes between Leishmania donovani and Leishmania infantum
- Mitochondrial fatty acid synthesis is required for normal mitochondrial morphology and function in Trypanosoma brucei
- TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex
- Adaptation of Trypanosoma brucei to gradual loss of kinetoplast DNA: Trypanosoma equiperdum and Trypanosoma evansi are petite mutants of T. brucei
- The import and function of diatom and plant frataxins in the mitochondrion of Trypanosoma brucei
- Ancestral roles of eukaryotic frataxin: mitochondrial frataxin function and heterologous expression of hydrogenosomal Trichomonas homologs in trypanosomes
- Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei
- Structure and function of the native and recombinant mitochondrial MRP1/MRP2 complex from
- A Cost-effective Amino-acid-type Selective Isotope Labeling of Proteins Expressed in Leishmania tarentolae
- Distribution and Phylogeny of EFL and EF-1α in Euglenozoa Suggest Ancestral Co-Occurrence Followed by Differential Loss
- Kinetoplastid guide RNA biogenesis is dependent on subunits of the mitochondrial RNA binding complex 1 and mitochondrial RNA polymerase
- Evolution of the serum resistance-associated SRA gene in African trypanosomes
- Cascades of convergent evolution: The corresponding evolutionary histories of euglenozoans and dinoflagellates
- The nuclear receptor NHR-25 cooperates with the Wnt/ .beta.-catenin asymmetry pathway to control differentiation of the T seam cell in C. elegans
- Mitochondrial tRNA import in Trypanosoma brucei is independent of thiolation and the Rieske protein
- Thiolation Controls Cytoplasmic tRNA Stability and Acts as a Negative Determinant for tRNA Editing in Mitochondria
- Selective recovery of the cultivation-prone components from mixed trypanosomatid infections: a case of several novel species isolated from Neotropical Heteroptera
- Interaction between Drosophila bZIP proteins Atf3 and Jun prevents replacement of epithelial cells during metamorphosis
- Crosstalk between a nuclear receptor and beta-catenin signaling decides cell fates in the C. elegans somatic gonad
- Photoperiodic and food signals control expression pattern of the clock gene, period, in the linden bug, Pyrrhocoris apterus
- Trypanosoma brucei 29-13 strain is inducible in but not permissive for the tsetse fly vector
- Sergeia podlipaevi gen. nov., sp. nov. (Trypanosomatidae, Kinetoplastida), a parasite of biting midges (Ceratopogonidae, Diptera)
- Description of Rhynchopus euleeides n. sp. (Diplonemea), a free-living, marine euglenozoan
- Unusual mitochondrial genome structures throughout the Euglenozoa
- The Leishmania donovani complex: Genotypes of five metabolic enzymes (ICD, ME, MPI, G6PDH and FH), new targets for multilocus sequence typing
- Characterization of the NADH:ubiquinone oxidoreductase (complex I) in the trypanosomatid Phytomonas serpens (Kinetoplastida)
- Evolutionary and geographical history of the Leishmania donovani complex with a revision of current taxonomy
- Circadian rhythm gene regulation in the housefly, Musca domestica
- The 2’-O-ribose methyltransferase for cap 1 of spliced leader RNA and U1 small nuclear RNA in Trypanosoma brucei
- How a Neutral Evolutionary Ratchet Can Build Cellular Complexity
- New Species of Insect Trypanosomatids from Costa Rica and the Proposal for a New Subfamily within the Trypanosomatidae
|
| is http://linked.open...vavai/cep/projekt
of | |
![[RDF Data]](/fct/images/sw-rdf-blue.png)
![[cxml]](/fct/images/cxml_doc.png)
![[csv]](/fct/images/csv_doc.png)
![[text]](/fct/images/ntriples_doc.png)
![[turtle]](/fct/images/n3turtle_doc.png)
![[ld+json]](/fct/images/jsonld_doc.png)
![[rdf+json]](/fct/images/json_doc.png)
![[rdf+xml]](/fct/images/xml_doc.png)
![[atom+xml]](/fct/images/atom_doc.png)
![[html]](/fct/images/html_doc.png)