About: How a Neutral Evolutionary Ratchet Can Build Cellular Complexity

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Here, we describe how complex machines might evolve in the absence of positive selection through a process of %22presuppression,%22 first termed constructive neutral evolution (CNE) more than a decade ago. If an autonomously functioning cellular component acquires mutations that make it dependent for function on another, preexisting component or process, and if there are multiple ways in which such dependence may arise, then dependence inevitably will arise and reversal to independence is unlikely. Thus, CNE is a unidirectional evolutionary ratchet leading to complexity, if complexity is equated with the number of components or steps necessary to carry out a cellular process. CNE can explain %22functions%22 that seem to make little sense in terms of cellular economy, like RNA editing or splicing, but it may also contribute to the complexity of machines with clear benefit to the cell, like the ribosome, and to organismal complexity overall. Here, we describe how complex machines might evolve in the absence of positive selection through a process of %22presuppression,%22 first termed constructive neutral evolution (CNE) more than a decade ago. If an autonomously functioning cellular component acquires mutations that make it dependent for function on another, preexisting component or process, and if there are multiple ways in which such dependence may arise, then dependence inevitably will arise and reversal to independence is unlikely. Thus, CNE is a unidirectional evolutionary ratchet leading to complexity, if complexity is equated with the number of components or steps necessary to carry out a cellular process. CNE can explain %22functions%22 that seem to make little sense in terms of cellular economy, like RNA editing or splicing, but it may also contribute to the complexity of machines with clear benefit to the cell, like the ribosome, and to organismal complexity overall. (en)
Title	How a Neutral Evolutionary Ratchet Can Build Cellular Complexity How a Neutral Evolutionary Ratchet Can Build Cellular Complexity (en)
skos:prefLabel	How a Neutral Evolutionary Ratchet Can Build Cellular Complexity How a Neutral Evolutionary Ratchet Can Build Cellular Complexity (en)
skos:notation	RIV/60077344:_____/11:00364838!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	7
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lukeš, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	202788
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00364838
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	neutral evolution; adaptation; selection (en)
http://linked.open.../riv/klicoveSlovo	adaptation selection neutral evolution
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[BF8ACA6DBBAF]
http://linked.open...i/riv/nazevZdroje	Iubmb Life
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	63
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Archibald, J. M. Gray, M. W. Doolittle, W. F. Keeling, P. J.
http://linked.open...ain/vavai/riv/wos	000292944000011
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1521-6543
number of pages	10 (xsd:int)
http://bibframe.org/vocab/doi	10.1002/iub.489
is http://linked.open...avai/riv/vysledek of	How a Neutral Evolutionary Ratchet Can Build Cellular Complexity

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