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rdf:type
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Description
| - Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the %22donor VSG%22, which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation.
- Serum resistence-associated (SRA) protein, a protein unique for Trypanosoma brucei rhodesiense, is responsible for resistance of this parasite to the lysis by normal human serum (NHS) and is a vital molecular marker to distinguish this species from other African trypanosomes. We cloned and sequenced the SRA basic copy (SRAbc) gene from T. b. rhodesiense and related species and found that this gene is confined to the subgenus Trypanozoon. The average 82% identity among the sequenced SRAbc genes indicated that they may have a common origin and are highly conserved. Since SRAbc coexists in the T rhodesiense genome with SRA, we propose that SRAbc might be the %22donor VSG%22, which after duplication became inserted into the expression site by recombination. Under natural selection, SRAbc could reform into SRA following mosaic formation. (en)
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Title
| - Evolution of the serum resistance-associated SRA gene in African trypanosomes
- Evolution of the serum resistance-associated SRA gene in African trypanosomes (en)
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skos:prefLabel
| - Evolution of the serum resistance-associated SRA gene in African trypanosomes
- Evolution of the serum resistance-associated SRA gene in African trypanosomes (en)
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skos:notation
| - RIV/60077344:_____/09:00334919!RIV10-MSM-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(2B06129), V, Z(AV0Z60220518)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/09:00334919
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - SRA; SRAbc; evolution; African trypanosomes (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - CN - Čínská lidová republika
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Lukeš, Julius
- Lai, D. H.
- Lun, Z. R.
- Wang, Q.P.
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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