About: Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei

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About: Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trypanosoma brucei je pro genetické studie nejpřístupnější reprezentant domény Excavata a rovněž původce lidské spavé nemoci a nagany u přežvýkavců. Pokusili jsme se zachránit buňky T. brucei s eliminovaným frataxinem vložením lidského frataxinu, jehož defekt u člověka způsobuje Friedrichovu ataxii. I přes obrovskou evoluční vzdálenost mezi člověkem a trypanosomami byl lidský frataxin nejen schopný účinného importu do mitochondrie T. brucei prostřednictvím původního importního signálu, ale rovněž dokázal zachránit jinak letální fenotyp. Záchrana buněk byla zcela závislá na mitochondriální lokalizaci lidského frataxinu. (cs) Trypanosoma brucei is the most genetically tractable representative of the domain Excavata and also the causative agent of human sleeping sickness and ruminant nagana. We have attempted to rescue the T. brucei cells with down-regulated frataxin using the human frataxin, the defects of which result in Friedriech’s ataxia. Despite the evolutionary distance between humans and trypanosomes, human frataxin was not only efficiently imported into the T. brucei mitochondrion via its long genuine import signal, but also successfully rescued the phenotype. The rescue was, however, fully dependent on mitochondrial localization of human frataxin. Trypanosoma brucei is the most genetically tractable representative of the domain Excavata and also the causative agent of human sleeping sickness and ruminant nagana. We have attempted to rescue the T. brucei cells with down-regulated frataxin using the human frataxin, the defects of which result in Friedriech’s ataxia. Despite the evolutionary distance between humans and trypanosomes, human frataxin was not only efficiently imported into the T. brucei mitochondrion via its long genuine import signal, but also successfully rescued the phenotype. The rescue was, however, fully dependent on mitochondrial localization of human frataxin. (en)
Title	Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei (en) Mitochondriální lokalizace ale ne procesování lidského frataxinu jsou esenciální pro záchranu frataxinové deficiente u Trypanosoma brucei (cs)
skos:prefLabel	Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei (en) Mitochondriální lokalizace ale ne procesování lidského frataxinu jsou esenciální pro záchranu frataxinové deficiente u Trypanosoma brucei (cs)
skos:notation	RIV/60077344:_____/08:00318331!RIV09-GA0-60077344
http://linked.open...avai/riv/aktivita	P Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/06/1558), P(IAA500960705), P(LC07032), Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	36
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Jirků, Milan Lukeš, Julius Long, Shaojun
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	379647
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/08:00318331
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	frataxin; mitochondrion; Trypanosoma; Kinetoplastida (en)
http://linked.open.../riv/klicoveSlovo	mitochondrion Trypanosoma Kinetoplastida frataxin
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[5140389880ED]
http://linked.open...i/riv/nazevZdroje	Proceeding of the National Academy of Science of the United Stated of America
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	4 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Center for Functional Genetics Functional analysis of mitochondrial proteins in Trypanosoma brucei The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	105
http://linked.open...iv/tvurceVysledku	Jirků, Milan Lukeš, Julius Long, Shaojun Ayala, F. J.
http://linked.open...ain/vavai/riv/wos	000259251700053
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1091-6490
number of pages	6 (xsd:int)
is http://linked.open...avai/riv/vysledek of	Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei Mitochondrial localization of human frataxin is necessary but processing is not for rescuing frataxin deficiency in Trypanosoma brucei

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