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rdf:type
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Description
| - We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/β-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/β-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character than in the C. elegans somatic gonad, where NHR-25 was shown to antagonize a β-catenin pathway.
- We show that an impaired function of the nuclear receptor NHR-25 abolishes differentiation of the neural T cell lineage similarly to mutations in Wnt/β-catenin asymmetry signaling pathwaycomponents. By means of genetic interactionwe demonstrate that NHR-25 cooperates with the Wnt/β-catenin pathway and with a parallel RUNX signaling to establish the correct fate of T cell daughters. Strikingly, the positive interaction between NHR-25 and Wnt/ catenin signaling in the T cell has an opposite character than in the C. elegans somatic gonad, where NHR-25 was shown to antagonize a β-catenin pathway. (en)
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Title
| - Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell
- Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell (en)
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skos:prefLabel
| - Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell
- Nuclear receptor NHR-25 interacts with Wnt/β-catenin signaling to direct differentiation of the C. elegans T cell (en)
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skos:notation
| - RIV/60077344:_____/09:00336504!RIV10-MSM-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(2B06129), P(GA204/07/0948), P(GD204/09/H058), Z(AV0Z50070508), Z(AV0Z60220518)
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/09:00336504
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Caenorhabditis elegans; asymmetric cell divisions; cell differentiation (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...ontrolniKodProRIV
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...iv/tvurceVysledku
| - Jindra, Marek
- Asahina, Masako
- Hajdušková, Martina
- Herman, M. A.
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http://linked.open...n/vavai/riv/zamer
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