About: TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex

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About: TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex Goto Sponge NotDistinct Permalink

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	The uridine insertion/deletion RNA editing of kinetoplastid mitochondrial transcripts is performed by complex machinery involving a number of proteins and multiple protein complexes. Here we describe the effect of silencing of TbRGG1 gene by RNA interference on RNA editing in procyclic stage of Trypanosoma brucei. TbRGG1 is an essential protein for cell growth, the absence of which results in an overall decline of edited mRNAs, while the levels of never-edited mRNAs remain unaltered. Repression of TbRGG1 expression has no effect on editosome and the MRP1/2 complex. Moreover, based on its composition, we propose that this large protein complex is involved in RNA binding and therefore name it mitochondrial RNA binding complex 1 (MRB complex 1). The uridine insertion/deletion RNA editing of kinetoplastid mitochondrial transcripts is performed by complex machinery involving a number of proteins and multiple protein complexes. Here we describe the effect of silencing of TbRGG1 gene by RNA interference on RNA editing in procyclic stage of Trypanosoma brucei. TbRGG1 is an essential protein for cell growth, the absence of which results in an overall decline of edited mRNAs, while the levels of never-edited mRNAs remain unaltered. Repression of TbRGG1 expression has no effect on editosome and the MRP1/2 complex. Moreover, based on its composition, we propose that this large protein complex is involved in RNA binding and therefore name it mitochondrial RNA binding complex 1 (MRB complex 1). (en) Inserce a dalece uridinů do mitochondriálních transkriptů u kinetoplastid jsou prováděny složitou mašinerií zahrnující celou řadu proteinů a mnohé proteinové komplexy. Zde popisujeme důsledky vypnutí genu TbRGG1 pomocí RNA interference na editování RNA v procyklickém stádiu Trypanosoma brucei. TbRGG1 je protein esenciální pro růst a jeho nedostatek vede k celkovému poklesu editovaných mRNA, zatímco hladiny needitovaných mRNA se nemění. Vypnutí exprese TbRGG1 nemá vliv na editosom a MRP1/2 komplex. S ohledem na jeho složení navrhujeme, že se tento velký proteinový komplex účastní vazby RNA a nazýváme ho tudíž mitochondriální RNA-vážící komplex 1 (MRB komplex 1). (cs)
Title	TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex (en) TbRGG1 je součástí multiproteinového komplexu účastnícího se editování RNA u kinetoplastid (cs)
skos:prefLabel	TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex (en) TbRGG1 je součástí multiproteinového komplexu účastnícího se editování RNA u kinetoplastid (cs)
skos:notation	RIV/60077344:_____/08:00318143!RIV09-GA0-60077344
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/06/1558), P(GD524/03/H133), P(IAA500960705), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	5
http://linked.open...vai/riv/dodaniDat	2009
http://linked.open...aciTvurceVysledku	Lukeš, Julius Hashimi, Hassan Zíková, Alena
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	399084
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/08:00318143
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	Trypanosoma; mitochondrion; RNA editing; RNA binding (en)
http://linked.open.../riv/klicoveSlovo	RNA binding RNA editing mitochondrion Trypanosoma
http://linked.open...odStatuVydavatele	US - Spojené státy americké
http://linked.open...ontrolniKodProRIV	[0C90AFFEDD71]
http://linked.open...i/riv/nazevZdroje	R N A
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	3 (xsd:int)
http://linked.open...cetTvurcuVysledku	5 (xsd:int)
http://linked.open...vavai/riv/projekt	Biology, phylogeny and ecology of parasites at organismal and molecular level Model organisms as a key to the understanding of functions of disease-related human genes Center for Functional Genetics Functional analysis of mitochondrial proteins in Trypanosoma brucei The role of Trypanosoma brucei RNA binding proteins in mitochondrial transcript processing.
http://linked.open...UplatneniVysledku	2008
http://linked.open...v/svazekPeriodika	14
http://linked.open...iv/tvurceVysledku	Lukeš, Julius Hashimi, Hassan Panigrahi, A. K. Stuart, K. D. Zíková, Alena
http://linked.open...ain/vavai/riv/wos	000255184500019
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1355-8382
number of pages	11 (xsd:int)
is http://linked.open...avai/riv/vysledek of	TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex

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