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rdf:type
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Description
| - The uridine insertion/deletion RNA editing of kinetoplastid mitochondrial transcripts is performed by complex machinery involving a number of proteins and multiple protein complexes. Here we describe the effect of silencing of TbRGG1 gene by RNA interference on RNA editing in procyclic stage of Trypanosoma brucei. TbRGG1 is an essential protein for cell growth, the absence of which results in an overall decline of edited mRNAs, while the levels of never-edited mRNAs remain unaltered. Repression of TbRGG1 expression has no effect on editosome and the MRP1/2 complex. Moreover, based on its composition, we propose that this large protein complex is involved in RNA binding and therefore name it mitochondrial RNA binding complex 1 (MRB complex 1).
- The uridine insertion/deletion RNA editing of kinetoplastid mitochondrial transcripts is performed by complex machinery involving a number of proteins and multiple protein complexes. Here we describe the effect of silencing of TbRGG1 gene by RNA interference on RNA editing in procyclic stage of Trypanosoma brucei. TbRGG1 is an essential protein for cell growth, the absence of which results in an overall decline of edited mRNAs, while the levels of never-edited mRNAs remain unaltered. Repression of TbRGG1 expression has no effect on editosome and the MRP1/2 complex. Moreover, based on its composition, we propose that this large protein complex is involved in RNA binding and therefore name it mitochondrial RNA binding complex 1 (MRB complex 1). (en)
- Inserce a dalece uridinů do mitochondriálních transkriptů u kinetoplastid jsou prováděny složitou mašinerií zahrnující celou řadu proteinů a mnohé proteinové komplexy. Zde popisujeme důsledky vypnutí genu TbRGG1 pomocí RNA interference na editování RNA v procyklickém stádiu Trypanosoma brucei. TbRGG1 je protein esenciální pro růst a jeho nedostatek vede k celkovému poklesu editovaných mRNA, zatímco hladiny needitovaných mRNA se nemění. Vypnutí exprese TbRGG1 nemá vliv na editosom a MRP1/2 komplex. S ohledem na jeho složení navrhujeme, že se tento velký proteinový komplex účastní vazby RNA a nazýváme ho tudíž mitochondriální RNA-vážící komplex 1 (MRB komplex 1). (cs)
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Title
| - TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex
- TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex (en)
- TbRGG1 je součástí multiproteinového komplexu účastnícího se editování RNA u kinetoplastid (cs)
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skos:prefLabel
| - TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex
- TbRGG1, an essential protein involved in kinetoplastid RNA metabolism that is associated with a novel multiprotein complex (en)
- TbRGG1 je součástí multiproteinového komplexu účastnícího se editování RNA u kinetoplastid (cs)
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skos:notation
| - RIV/60077344:_____/08:00318143!RIV09-GA0-60077344
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http://linked.open...avai/riv/aktivita
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http://linked.open...avai/riv/aktivity
| - P(2B06129), P(GA204/06/1558), P(GD524/03/H133), P(IAA500960705), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
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http://linked.open...iv/cisloPeriodika
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http://linked.open...vai/riv/dodaniDat
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http://linked.open...aciTvurceVysledku
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http://linked.open.../riv/druhVysledku
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http://linked.open...iv/duvernostUdaju
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http://linked.open...titaPredkladatele
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http://linked.open...dnocenehoVysledku
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http://linked.open...ai/riv/idVysledku
| - RIV/60077344:_____/08:00318143
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http://linked.open...riv/jazykVysledku
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http://linked.open.../riv/klicovaSlova
| - Trypanosoma; mitochondrion; RNA editing; RNA binding (en)
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http://linked.open.../riv/klicoveSlovo
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http://linked.open...odStatuVydavatele
| - US - Spojené státy americké
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http://linked.open...ontrolniKodProRIV
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http://linked.open...i/riv/nazevZdroje
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http://linked.open...in/vavai/riv/obor
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http://linked.open...ichTvurcuVysledku
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http://linked.open...cetTvurcuVysledku
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http://linked.open...vavai/riv/projekt
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http://linked.open...UplatneniVysledku
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http://linked.open...v/svazekPeriodika
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http://linked.open...iv/tvurceVysledku
| - Lukeš, Julius
- Hashimi, Hassan
- Panigrahi, A. K.
- Stuart, K. D.
- Zíková, Alena
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http://linked.open...ain/vavai/riv/wos
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http://linked.open...n/vavai/riv/zamer
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issn
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number of pages
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is http://linked.open...avai/riv/vysledek
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