About: Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

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An Entity of Type : http://linked.opendata.cz/ontology/domain/vavai/Vysledek, within Data Space : linked.opendata.cz associated with source document(s)

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rdf:type	skos:Concept http://linked.opendata.cz/ontology/domain/vavai/Vysledek
Description	Trypanosome brucei undergoes two clearly distinct develomental stages: in the insect vector (procyclic stage) the cells generate the bulk of their energy through respiration, whereas in the bloodstream of the mammalian host (bloodstream stage) they grow mostly glycolytically. Several mitochondrial respiratory proteins require iron-sulfur clusters for activity, and their activation coincides with developmental changes. Likewise some tRNA modification enzymes either require iron-sulfur clusters or use components of the iron-sulfur cluster assembly pathway for activity. These enzymes affect the anticodon loop of various tRNAs and can impact protein synthesis. Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined. Trypanosome brucei undergoes two clearly distinct develomental stages: in the insect vector (procyclic stage) the cells generate the bulk of their energy through respiration, whereas in the bloodstream of the mammalian host (bloodstream stage) they grow mostly glycolytically. Several mitochondrial respiratory proteins require iron-sulfur clusters for activity, and their activation coincides with developmental changes. Likewise some tRNA modification enzymes either require iron-sulfur clusters or use components of the iron-sulfur cluster assembly pathway for activity. These enzymes affect the anticodon loop of various tRNAs and can impact protein synthesis. Herein, the possibility of these pathways being integrated and exploited by T. brucei to carefully coordinate energy demands to translational rates in response to enviromental changes is examined. (en)
Title	Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors (en)
skos:prefLabel	Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors (en)
skos:notation	RIV/60077344:_____/11:00364802!RIV12-MSM-60077344
http://linked.open...avai/predkladatel	Biologické centrum AV ČR, v. v. i.
http://linked.open...avai/riv/aktivita	P S Z
http://linked.open...avai/riv/aktivity	P(2B06129), P(GA204/09/1667), P(LC07032), S, Z(AV0Z60220518), Z(MSM6007665801)
http://linked.open...iv/cisloPeriodika	6
http://linked.open...vai/riv/dodaniDat	2012
http://linked.open...aciTvurceVysledku	Lukeš, Julius
http://linked.open.../riv/druhVysledku	J - Článek v odborném periodiku
http://linked.open...iv/duvernostUdaju	S - Úplné a pravdivé údaje nepodléhající ochraně podle zvláštních právních předpisů
http://linked.open...titaPredkladatele	Biologické centrum AV ČR, v. v. i.
http://linked.open...dnocenehoVysledku	187216
http://linked.open...ai/riv/idVysledku	RIV/60077344:_____/11:00364802
http://linked.open...riv/jazykVysledku	eng - angličtina
http://linked.open.../riv/klicovaSlova	IRON-SULFUR CLUSTERS; TRYPANOSOMA-BRUCEI; MITOCHONDRIAL; PROTEIN; FRATAXIN; BIOSYNTHESIS; SYNTHETASES; BIOGENESIS; THIOLATION; ANTICODON (en)
http://linked.open.../riv/klicoveSlovo	ANTICODON BIOGENESIS BIOSYNTHESIS FRATAXIN IRON-SULFUR CLUSTERS MITOCHONDRIAL PROTEIN SYNTHETASES THIOLATION TRYPANOSOMA-BRUCEI
http://linked.open...odStatuVydavatele	GB - Spojené království Velké Británie a Severního Irska
http://linked.open...ontrolniKodProRIV	[A9BEA981D33C]
http://linked.open...i/riv/nazevZdroje	Trends in Parasitology
http://linked.open...in/vavai/riv/obor	EB
http://linked.open...ichTvurcuVysledku	1 (xsd:int)
http://linked.open...cetTvurcuVysledku	2 (xsd:int)
http://linked.open...vavai/riv/projekt	Model organisms as a key to the understanding of functions of disease-related human genes Characterization of a novel protein complex involved in RNA processing and editing in the mitochondrion of Trypanosoma brucei Center for Functional Genetics
http://linked.open...UplatneniVysledku	2011
http://linked.open...v/svazekPeriodika	27
http://linked.open...iv/tvurceVysledku	Alfonzo, J. D. Lukeš, Julius
http://linked.open...ain/vavai/riv/wos	000292238800003
http://linked.open...n/vavai/riv/zamer	Parazitismus a parazito-hostitelské vztahy na organismální, buněčné a molekulové úrovni EKOLOGICKÉ, EVOLUČNÍ A EXPERIMENTÁLNĚ BIOLOGICKÉ PŘÍSTUPY KE STUDIU VZNIKU A VÝZNAMU BIODIVERZITY
issn	1471-4922
number of pages	4 (xsd:int)
http://bibframe.org/vocab/doi	10.1016/j.pt.2011.02.003
is http://linked.open...avai/riv/vysledek of	Assembling Fe/S-clusters and modifying tRNAs: ancient co-factors meet ancient adaptors

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